Prospective study of cataract extraction and risk of coronary heart disease in women.
نویسندگان
چکیده
Oxidative damage to proteins in the human lens is believed to be important in the etiology of age-related cataract. Because free radical-mediated oxidative damage to lipoproteins may accelerate atherosclerosis, the authors hypothesized that the development of cataract might be a marker for such damage and therefore might be associated with future risk of coronary heart disease (CHD). The authors followed 60,657 women aged 45--63 years and without known coronary disease, stroke, or cancer in 1984. During 10 years of follow-up (674,283 person-years), the authors documented 887 incident cases of CHD and 2,322 deaths. After adjustment for age, smoking, and other coronary risk factors, cataract extraction was significantly associated with higher risk of CHD (relative risk (RR) = 1.88, 95% confidence interval (CI): 1.41, 2.50) for total CHD, 2.44 (95% CI: 1.54, 3.89) for fatal CHD, and 1.63 (95% CI: 1.14, 2.34) for nonfatal myocardial infarction). The positive association between cataract extraction and total CHD was stronger among women with a history of diabetes (RR = 2.80, 95% CI: 1.77, 4.42) than among those without reported diabetes (RR = 1.51, 95 percent CI: 1.04, 2.18). In multivariate analyses, cataract extraction was associated with significantly increased overall mortality (RR = 1.37, 95 percent CI: 1.13, 1.66), which was entirely explained by the increased mortality from cardiovascular disease (RR = 1.84, 95% CI: 1.29, 2.64). These findings are compatible with current hypotheses relating oxidative damage and tissue aging to the development of cataract and CHD.
منابع مشابه
Prevalence of androgenetic alopecia in patients and its relationship with the history of coronary heart disease
Background and Aim: Androgenetic alopecia is a type of androgen and genetic dependent hair loss and although it is more of a beauty issue, but in recent years studies have shown that this type of alopecia is associated with underlying disorders such as coronary artery disease. The aim of this study was to evaluate the frequency of androgenetic alopecia in hospitalized patients and its relations...
متن کاملAssociation between Mental Health and Coronary Heart Disease: A Prospective Cohort Study
Background and purpose: According to some evidence, psychological factors play an important role in the development and progression of cardiac diseases. But there are contradictions about the independent relationship between psychological distress and coronary heart disease. The purpose of this study was to examine the association between mental health and non-fatal coronary heart disease (CH...
متن کاملPASSIVE SMOKING AND THE RISK OF CORONARY HEART DISEASE AMONG MARRIED NON-SMOKING WOMEN
Several epidemiological studies have reported that passive smoking (PS) is a public health hazard and perhaps increases the risk of heart disease. This study evaluated the relationship between female coronary heart disease and PS among married women who described themselves as non-smokers in an area of south-east Iran. Using household exposure to tobacco smoke as an estimate of PS, a hospi...
متن کاملPrevalence of Rose Questionnaire Angina and its Association with Coronary Heart Disease Risk Factors in Tehran, IR.Iran
Background: Rose questionnaire is a standard mean for diagnosing angina pectoris in epidemiological study. The present study was done to determine the prevalence of angina pectoris according to Rose questionnaire for chest pain, and to investigate the association of angina with several coronary hearh disease risk factors in Tehran urban population (district-13) during 1999 to 2000. Methods: 60...
متن کاملEffect of 12 weeks aerobic exercise on coronary heart diseases\' markers of inflammation in middle-aged women
Introduction: This study aims at analyzing the effect of 12 weeks physical exercise (30 minutes for three days a week: 70-85% of the maximum heart rate) on variations of inflammation markers in middle-aged women's Coronary Heart diseases (CHDs). Methods: In this study a total of 40 subjects including 40-55 years old women were selected purposively and were divided into two experimental and c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- American journal of epidemiology
دوره 153 9 شماره
صفحات -
تاریخ انتشار 2001